Creative Biogene possesses significant expertise and experience in microbial fermentation development and is dedicated to integrate world-wide resources for those who have demands for microbial factory manufacturing.
Fermentation is the process that engineered microorganisms produce large amounts of added-value intermediates or chemicals in a designed bioreactor. These products can be food supplements, pharmaceuticals, industrial platform compounds and others. Fermentation is a part of the upstream process and it occurs before recovery, purification, formulation, filling and packaging in the biomanufacturing workflow.
We have years of experience in fermentation process development and have abilities to outsource your fermentation project and save your time of research. Our services are aimed to provide clients fermentation services at the lab-scale and pilot scale level1 as well as upstream and downstream processing development for your RD projects.
Upstream Processing Services
• Strain selection and optimization
Our talented scientists work with diverse microorganisms including E.coli, yeast, fungi, bacillus, filamentous bacteria and marine based bacteria. We have years of experience in strain genetic engineering and have the cutting-edge fermentation technologies used for clone selection and optimization.
• Fermentation process optimization
Before the large-scale fermentation, fermentation process optimization is one of the most crucial parts to achieve a high yield production and a relatively low cost. Our professional staffs have extensive strategies and techniques to optimize the culture condition such as the medium, temperature, pH, dissolved oxygen through classical optimization methods. These methods comprise statistical medium optimization, response surface methodology and other technologies.
Downstream Processing Development Services
Creative Biogene offers extensive downstream processing services including broth recovery, separation of biomass, cell disruption, purification, analytical and packaging services. The products can be biomass, chemical, small bioactive molecules. Coupled with our integrated technology, wide spectrum of development tools and advanced manufacturing systems, we can help you handle any downstream processing problems.
